{"product_id":"estrovantage-em","title":"EstroVantage EM® Estrogen Modulator, Bioclinic, 90 vcaps","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv class=\"uses_benefits\"\u003e\n\u003cp\u003e\u003cstrong\u003eBenefits:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.\u003c\/li\u003e\n\u003cli\u003eIn a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (\u003cem\u003eRosemarinus officinalis\u003c\/em\u003e), were found to be a promising adjuvant therapy in advanced breast cancer patients\u003c\/li\u003e\n\u003cli\u003eGreen tea polyphenols inhibit the proliferation of breast cancer cells\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ein vivo\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ein vitro\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003eSilymarin can down-regulate gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)\u003c\/li\u003e\n\u003cli\u003eCurcumin inhibits human breast cancer cell growth by mediating certain signalling cascades including the modulation of the NF-κB signalling pathway\u003c\/li\u003e\n\u003cli\u003eSulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression\u003c\/li\u003e\n\u003cli\u003eSuitable for vegetarians\/vegans \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"feature_summary\"\u003e\n\u003cp\u003e\u003cstrong\u003eFeature Summary:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol.\u003cspan\u003e \u003c\/span\u003eIn premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.\u003cspan\u003e \u003c\/span\u003eAs such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.\u003cspan\u003e \u003c\/span\u003eSeveral natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.\u003cspan\u003e \u003c\/span\u003eOther compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.\u003cspan\u003e \u003c\/span\u003eIt is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv class=\"medicinal_ingredients\"\u003e\n\u003cp\u003e\u003cstrong\u003eMedicinal Ingredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eServing Size: 3 Vegetarian Capsules\u003cbr\u003eServings per Container: 60\u003c\/p\u003e\n\u003cp\u003eEach Capsule Contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e - 75 mg\u003c\/li\u003e\n\u003cli\u003eIndole-3-Carbinol (3-Hydroxymethylindole) - 75 mg\u003c\/li\u003e\n\u003cli\u003eGreen Tea Extract (\u003cem\u003eCamellia sinensis\u003c\/em\u003e) (leaf) (80% Catechins, 45% EGCg*, \u0026lt;1% Caffeine) - 50 mg\u003c\/li\u003e\n\u003cli\u003eTomato Extract (\u003cem\u003eLycopersicon esculentum\u003c\/em\u003e) (fruit) (5% Lycopene) - 50 mg\u003c\/li\u003e\n\u003cli\u003eBroccoli Powder (\u003cem\u003eBrassica oleracea var. italica\u003c\/em\u003e) (aerial) (0.36% Sulforaphane) - 27.5 mg\u003c\/li\u003e\n\u003cli\u003eDIM (3,3’-Diindolylmethane) - 25 mg\u003c\/li\u003e\n\u003cli\u003eTurmeric Extract (\u003cem\u003eCurcuma longa\u003c\/em\u003e) (rhizome) (95% Curcuminoids) - 25 mg\u003c\/li\u003e\n\u003cli\u003eMilk Thistle Extract (\u003cem\u003eSilybum marianum\u003c\/em\u003e) (seed) (50–60% Silymarin) - 25 mg\u003c\/li\u003e\n\u003cli\u003eRosemary Extract (\u003cem\u003eRosmarinus officinalis\u003c\/em\u003e) (leaf) - 12.5 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e* Epigallocatechin-3-gallate\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"non_medicinal_ingredients\"\u003e\n\u003cp\u003e\u003cstrong\u003eNon-Medicinal Ingredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"allergens\"\u003e\n\u003cp\u003e\u003cstrong\u003eAllergens:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eContains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians\/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"recommended_use\"\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended Use:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.\u003c\/p\u003e\n\u003cp\u003eNPN 80044252\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Bioclinic","offers":[{"title":"Default Title","offer_id":12887046914106,"sku":"80044252","price":42.99,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0022\/7039\/6474\/products\/80044252-estrovantage-em.png?v=1618266160","url":"https:\/\/shop.rediscoverhealth.ca\/en-ru\/products\/estrovantage-em","provider":"Rediscover Health Online Dispensary ","version":"1.0","type":"link"}