{"product_id":"gpc-liquid-59-ml-glycerophosphocholine","title":"GPC Liquid 59 ml Glycerophosphocholine","description":"\u003cmeta charset=\"UTF-8\"\u003e\n\u003cdiv title=\"Page 1\" class=\"page\"\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cp\u003e\u003cspan\u003eCholine is a semi-essential nutrient with a recommended adequate intake (AI) from the Institute of Medicine of 425mg\/550mg per day (for females\/males, respectively).\u003c\/span\u003e\u003cspan\u003e47 \u003c\/span\u003e\u003cspan\u003eMany people fail to obtain adequate amounts of choline,\u003c\/span\u003e\u003cspan\u003e40 \u003c\/span\u003e\u003cspan\u003eand endogenous synthesis (from phosphatidylethanolamine) is limited. Aging, genetic polymorphisms and estrogen deficiency may increase the demand for choline even above the AI.\u003c\/span\u003e\u003cspan\u003e43-46\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eGlycerophosphocholine (GPC, also known as L-alpha-glycerylphosphorylcholine or choline alfoscerate) is a naturally occurring source of choline contained in small amounts in various foods (including mother’s milk) and in all human cells. GPC is a watersoluble molecule and has been proven to be a more clinically effective source of choline compared to choline or phosphatidylcholine (PC) from diet or supplements.\u003c\/span\u003e\u003cspan\u003e9,22-25\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOral GPC is well absorbed and is cleaved inside enterocytes into glycerol-1-phosphate and choline. Following GPC ingestion, the plasma level of choline rises rapidly and remains elevated for up to ten hours. A high plasma concentration gradient of choline stimulates its transport through the blood brain barrier with high efficiency. This increases choline reserves inside neurons, where it is used for synthesis of PC and acetylcholine.\u003c\/span\u003e\u003cspan\u003e1, 22-25\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eRESEARCH HAS DEMONSTRATED THE FOLLOWING POTENTIAL EFFECTS OF GPC:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBrain Function\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eHelps support memory, mental focus and reaction time in elderly and young individuals\u003c\/span\u003e\u003cspan\u003e1-3,15,51,52\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eBoosts acetylcholine (ACh) production and release from neurons and likely other cells\u003c\/span\u003e\u003cspan\u003e22,23\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMay compensate for ACh decline due to aging, estrogen deficiency (menopause, possibly also with oral contraceptive \u003c\/span\u003e\u003cspan\u003euse)\u003c\/span\u003e\u003cspan\u003e1,54,41\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSupports healthy EEG patterns\u003c\/span\u003e\u003cspan\u003e20\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSupports normal production of dopamine,\u003c\/span\u003e\u003cspan\u003e30 \u003c\/span\u003e\u003cspan\u003eserotonin\u003c\/span\u003e\u003cspan\u003e30 \u003c\/span\u003e\u003cspan\u003eand GABA\u003c\/span\u003e\u003cspan\u003e18\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSupports mitochondrial function during ischemia\/oxidative stress\u003c\/span\u003e\u003cspan\u003e29\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003ePlays a role in the prevention or slowing of age-dependent reduction in number of brain cells\u003c\/span\u003e\u003cspan\u003e49 \u003c\/span\u003e\u003cspan\u003eand ACh receptors\u003c\/span\u003e\u003cspan\u003e50\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMuscle Function and Growth Hormone Metabolism\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003e• Supports natural growth hormone production in the young and elderly\u003c\/span\u003e\u003cspan\u003e8,27,28,55 \u003c\/span\u003e\u003cspan\u003e• Supports optimal fat oxidation,\u003c\/span\u003e\u003cspan\u003e55 \u003c\/span\u003e\u003cspan\u003emuscle strength\u003c\/span\u003e\u003cspan\u003e26,28 \u003c\/span\u003e\u003cspan\u003eand reaction time\u003c\/span\u003e\u003cspan\u003e51,52\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBrain Health\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e• Supports the natural recovery process of the brain, which may be beneficial after stroke,\u003c\/span\u003e\u003cspan\u003e5-7 \u003c\/span\u003e\u003cspan\u003ecranial injury\u003c\/span\u003e\u003cspan\u003e56 \u003c\/span\u003e\u003cspan\u003eand anesthesia (pre- and post-surgery)\u003c\/span\u003e\u003cspan\u003e39\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSupports blood brain barrier tissue health, which can be damaged by hypertension\u003c\/span\u003e\u003cspan\u003e33\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eHelps support healthy cognition and social behavior in Alzheimer’s disease,\u003c\/span\u003e\u003cspan\u003e4,9,16,17 \u003c\/span\u003e\u003cspan\u003evascular\/age-related dementia,\u003c\/span\u003e\u003cspan\u003e10-12 \u003c\/span\u003e\u003cspan\u003eand\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eParkinson’s disease\u003c\/span\u003e\u003cspan\u003e22-25\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMay play a role in the reduction of brain volume shrinkage\u003c\/span\u003e\u003cspan\u003e48\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMay be beneficial for conditions requiring a healthy natural myelin repair process, and Duchenne muscular dystrophy\u003c\/span\u003e\u003cspan\u003e1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cp\u003e\u003cspan\u003eDesigns for Health \u003c\/span\u003e\u003cspan\u003eand logo are trademarks of Designs for Health, Inc.\u003c\/span\u003e\u003cspan\u003e© \u003c\/span\u003e\u003cspan\u003e2020 Designs for Health, Inc. All rights reserved.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cp\u003e\u003cspan\u003e877.414.9388 • DESIGNSFORHEALTH.CA • CANADAORDERS@DESIGNSFORHEALTH.COM\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv title=\"Page 2\" class=\"page\"\u003e\n\u003cdiv class=\"section\"\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cp\u003e\u003cspan\u003eFUNCTIONS OF CHOLINE IN HUMAN METABOLISM\u003cbr\u003eBuilding block for ACh and stimulator of its synthesis and secretion\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e• ACh is a neurotransmitter in the brain and signal transducer in the rest of the body essential for muscle contraction, skin\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003etone, GI motility and other tissue functions. Unlike choline\/PC provided through diet or supplements, GPC supplementation was shown to have a significant stimulatory effect on ACh synthesis and its release from cholinergic cells.\u003c\/span\u003e\u003cspan\u003e22-25 \u003c\/span\u003e\u003cspan\u003eOne study found that GPC supplementation in rats resulted in approximately 123% higher content of ACh in the frontal cortex compared to controls.\u003c\/span\u003e\u003cspan\u003e31 \u003c\/span\u003e\u003cspan\u003eThe dose employed was equivalent to a human dose of 24mg\/kg body weight, which translates to a daily dose of 1200mg for a 50kg human.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eGPC supplementation may result in enhanced cholinergic signaling from neurons and likely other cells that produce ACh. This is especially beneficial when the number and effective functioning of cholinergic neurons are diminished due to normal aging or various degenerative processes. GPC supplementation has the potential to partially compensate for these impairments because it produces a fast rise in plasma choline, which creates a powerful substrate mass action on enzymes and transporters in these pathways.\u003c\/span\u003e\u003cspan\u003e24\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBuilding block for phosphatidylcholine (PC)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e• The choline derived from GPC supplementation is partially used for PC synthesis.\u003c\/span\u003e\u003cspan\u003e24 \u003c\/span\u003e\u003cspan\u003ePC belongs to the class of phospholipids, which are essential components of cell and mitochondrial membranes. The ability of GPC supplementation to help support the recovery from stroke,\u003c\/span\u003e\u003cspan\u003e5-7 \u003c\/span\u003e\u003cspan\u003eas well as to counteract the age-dependent reduction of nerve cells or number of ACh receptors in the brain,\u003c\/span\u003e\u003cspan\u003e49,50 \u003c\/span\u003e\u003cspan\u003eserve as additional evidence for its contribution to neuronal membrane maintenance through PC synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFormation of sphingomyelin\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e• Sphingomyelin is a building block for the myelin that covers and insulates neurons and nerves.\u003c\/span\u003e\u003cspan\u003e22-25 \u003c\/span\u003e\u003cspan\u003eThus, GPC supplementation may be useful in any condition with increased need for an optimal myelin repair process.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFat transport in and out of cells\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e• PC is required for the synthesis and secretion of VLDL particles. Triglycerides exit the liver inside VLDL particles, which explains why choline deficiency increases the risk of developing fatty liver.\u003c\/span\u003e\u003cspan\u003e43-46 \u003c\/span\u003e\u003cspan\u003ePC can be obtained from food sources or supplements; however, the PC used in phospholipids and lipoproteins is not derived directly from ingested or pre-formed PC. It is synthesized from various choline precursors, including GPC, so taking in PC is not necessarily the most effective way to increase the body’s pool of PC.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSupports sperm motility\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e• GPC is a key factor in the attachment of DHA (docosahexaenoic acid) to make PC-DHA. The DHA-PC complex is used in highly active cell types, such as retinal light-sensing cells and sperm cells. DHA-PC increases membrane fluidity, which is crucial for healthy sperm function. Semen contains a high concentration of GPC; the epididymal cells that nurture sperm cells draw from a pool of GPC to synthesize PC-DHA. Lower levels of GPC and PC-DHA in the semen may increase risk for reduced sperm motility.\u003c\/span\u003e\u003cspan\u003e1,57\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eComparison between GPC and acetyl-L-carnitine (ALCAR)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e• In a study of patients with advanced Alzheimer’s disease, GPC produced more significant improvements in most neuro-psychological parameters compared to ALCAR.16 While both compounds support increased production of acetylcholine, it is conceivable that there could be synergy between supplementation with both these compounds since GPC provides the choline while ALCAR provides the acetyl component for ACh synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eConsider using GPC along with other Designs for Health products formulated to support brain and nerve function such as Brain VitaleTM, OmegAvailTM Ultra DHA, Acetyl-L-Carnitine, and Mitochondrial NRGTM.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMedicinal Ingredients (2 ml - approx. 2 droppers full):\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eGlycerophosphocholine (Choline alfoscerate from sunflower lecithin) ....................................................................................... 600 mg \u003c\/span\u003e\u003cspan\u003eNon-Medicinal Ingredients: \u003c\/span\u003e\u003cspan\u003eVegetable glycerine, deionized water. \u003c\/span\u003e\u003cspan\u003eRecommended Dose: \u003c\/span\u003e\u003cspan\u003eAdults: Take 2 ml per day, or as directed by your health care practitioner.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Designs for Health","offers":[{"title":"Default Title","offer_id":39744243531879,"sku":"80072727","price":92.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0022\/7039\/6474\/products\/GPC-Liquid-CN_2_20fl_20oz_20_59_20mL__20liquid-1_1.png?v=1655601708","url":"https:\/\/shop.rediscoverhealth.ca\/en-ru\/products\/gpc-liquid-59-ml-glycerophosphocholine","provider":"Rediscover Health Online Dispensary ","version":"1.0","type":"link"}