The microbial ecosystem in the gastrointestinal (GI) tract has emerged as a “virtual organ system”, with growing recognition of its diverse significance in both health maintenance and disease prevention.1 GI microbiota play a critical role in maintaining homeostasis of the innate and cell-mediated immune system and enhance intestinal barrier function through a number of mechanisms, including toxin metabolism, tight junction protein phosphorylation and inflammation reduction.2 Research has clearly shown the importance of intestinal bacteria not just for maintaining optimal gastro-intestinal health, but also for chronic and systemic health conditions such as type 2 diabetes, obesity, and other inflammatory or autoimmune diseases.3-6
Probiotics have multifactorial benefits, by modulating gut immune responses and intestinal barrier functions in a strain and dose-dependent manner. Additionally, mixtures of probiotics appear to have greater efficacy than single strains, perhaps because of synergistic activity or because individuals react differently to various strains.7-10
Probiotic-Pro12 contains 12 bacterial species, each chosen because they can withstand both gastric acid and high-bile concentrations, and for their proven benefits in clinical research, mediated via individual mechanisms of action. The high-quality lactic acid bacteria requires considerable care at all times, therefore over 20 stringent quality control measures are implemented to ensure strain consistency and viability right up until finished product.
|Each Capsule Contains:|
|12 billion active cells* of the following specially cultured strains of probiotics:|
|Total bacterial culture||12 billion cfu|
|Lactobacillus casei (HA-108) (whole cell) (human)||25%||3.00 billion cfu|
|Lactobacillus rhamnosus (HA-111) (whole cell) (human)||12%||1.44 billion cfu|
|Bifidobacterium breve (HA-129) (whole cell) (human)||10%||1.20 billion cfu|
|Bifidobacterium longum subsp.?longum (HA-135) (whole cell) (human)||10%||1.20 billion cfu|
|Lactobacillus acidophilus (HA-122) (whole cell) (human)||10%||1.20 billion cfu|
|Lactobacillus plantarum (HA-119) (whole cell) (plant)||10%||1.20 billion cfu|
|Lactobacillus rhamnosus (HA-114) (whole cell) (human)||10%||1.20 billion cfu|
|Bifidobacterium bifidum (HA-132) (whole cell) (human)||5%||0.60 billion cfu|
|Lactobacillus fermentum (HA-179) (whole cell) (dairy)||5%||0.60 billion cfu|
|Lactobacillus salivarius (HA-118) (whole cell) (human)||1%||0.12 billion cfu|
|Lactobacillus paracasei (HA-196) (whole cell) (dairy)||1%||0.12 billion cfu|
|Bifidobacterium animalis subsp.?lactis (HA-194) (whole cell) (dairy)||1%||0.12 billion cfu|
|cfu: colony forming units
*Guaranteed minimum 12 billion active cells per capsule at expiry date.
Guaranteed minimum 18 billion active cells per capsule at manufacture date.
Maltodextrin, vegetarian capsule (carbohydrate gum [cellulose], purified water), fructooligosaccharides (naturally occurring complex fructose molecules derived from beets), inulin (chicory), vegetable grade magnesium stearate (lubricant), silica, ascorbic acid.
Contains no artificial colours, preservatives, or sweeteners; no wheat, gluten, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians.
Recommended Adult Dose: 1–3 capsules per day on a full stomach or as directed by a health care practitioner. Take at least 2–3 hours before or after antibiotics.