Feature Summary

Vitamin D and omega-3 fatty acids from fish oil are among the most powerful nutrients for improving overall health, and they are also among the most commonly deficient.^3,4 EPA and DHA improve a number of cardiovascular risk factors, including lowering of atherosclerotic burden, reducing triglyceride levels and blood pressure, and improving platelet and vascular function.5-8 Not only do these fatty acids modulate risk factors, but controlled clinical trials have shown them to be effective in preventing cardiovascular and coronary events, particularly in persons at high risk.^9,10

EPA and DHA also support cognitive function through multiple mechanisms, as they are indispensable to neuronal membranes, with lower levels found to be not only a marker for neurological disease, but also a risk factor for cognitive impairment.^11,12 EPA and DHA are essential to the resolution of inflammatory processes, providing the substrates for anti-inflammatory prostaglandins, resolvins and protectins.^13-15

Vitamin D modifies cardiovascular risk and reduces the risk of autoimmune disease and osteoporotic fractures.^16-20 It has also been shown to have anti-inflammatory effects, with supplementation particularly important for those with signs of inflammation.^21,22 Insufficient intake of vitamin D and EPA/DHA has been implicated in brain dysfunction, including impaired serotonin activation, cognitive decline, ADHD, and mood disorders.^23-28 EPA and DHA, combined with vitamin D, have synergistic benefits for improving overall wellness.^29-31