What is CoQ10?
Coenzyme Q10 (CoQ10), also known as ubiquinone, is a proenzyme produced naturally within the body. CoQ10 playsa critical role in energy (ATP) production and is an antioxidant for the maintenance of good health. CoQ10 inhibits protein and lipid oxidation and protects mitochondrial DNA from oxidative damage. CoQ10300 mg is delivered in a proprietary oil-based formulation and includes natural vitamin E for
enhanced absorption and maximum stability.

Overview
CoQ10 is a lipid-soluble antioxidant found in every cell in the body. CoQ10 is abundant in the mitochondrial membrane and plays an important role in the synthesis of adenosine triphosphate (ATP), a molecule of chemical energy upon which all cellular functions depend. The synthesis of ATP within the mitochondria is a multi-step series of biochemical reactions called the electron transport chain. As a coenzyme, CoQ10 is required for several enzymatic reactions required to produce
cellular energy and to protect the body against free radicals produced during this process. To maintain energy production, mitochondrial CoQ10 is continuously recycled from ubiquinone, its ATP production state, to ubiquinol, its antioxidant state.
After the age of 35 to 40 years, endogenous synthesis of CoQ10 begins to decline. 1
CoQ10, an essential component of cellular energy production, has been shown to benefit high-energy systems, namely the cardiovascular system. Supplementation with a highly concentrated, oil-based CoQ10 enables faster recovery of CoQ10 levels for those that have increased CoQ10 requirements including: those with drug-induced depletion, increasing age, or increased tissue demands. The safety of CoQ10 at high doses has been tested in a double-blind, placebo-controlled study.2 The findings in this study showed that CoQ10 was well tolerated and safe at a high intake (900 mg/day).2 CoQ10 Depletion The body’s ability to produce and metabolize CoQ10 has been reported to decrease with age. CoQ10 deficiency may be caused
by insufficient dietary intake of CoQ10, impairment in CoQ10 production, drug-induced CoQ10 depletion, gene mutations, and oxidative stress. HMG-CoA reductase is an enzyme required for the synthesis of cholesterol and CoQ10. Cholesterol lowering medications inhibit this enzyme in order to reduce cholesterol synthesis, but may also simultaneously deplete CoQ10 status. Thirteen controlled studies conducted between 1990-2004 demonstrated significant CoQ10 depletion, secondary to use of statin medications used to lower cholesterol levels.3 These
studies demonstrated a range of 19-54% decrease in CoQ10 levels in patients on statin therapy. In the event of CoQ10 depletion, supplementation can improve CoQ10 status and help maintain optimal levels in the body.

Antioxidant Protection
Oxidative stress is a condition that occurs when there is an imbalance between free radicals and the antioxidants required to neutralize them, leading to oxidative damage in the body. The extent of oxidative stress depends on the rate of free
radical generation, the level of antioxidant reserves and the rate of repair of cellular and tissue damage. This process has a significant impact on the body’s aging process. In its role in electron transport, CoQ10 continuously goes through anoxidation-reduction cycle in order to neutralize free radicals and provide significant protection against toxic oxidative reactions in the body.

Cardiovascular Health
CoQ10 is important for all energy-dependent processes, and is especially helpful in strengthening contraction of the heart muscle. CoQ10 is also important for protection against free radical damage to the arterial vessels.

Recommended Dose
Adults: Take 1 capsule per day.
Medicinal Ingredients (per capsule)
Coenzyme Q10 (Rhodobacter sphaeroides - Whole Cell for Biosynthesis)........300 mg
Vitamin E (d-alpha Tocopherol).........................................................20.1 mg AT (30 IU)

Tocopherols

(Mixed Tocopherols concentrate, Glycine max - Seed).........................................15 mg

Non-Medicinal Ingredients
Gelatin, Glycerin, Purified water, Ceratonia Siliqua (Carob) Fruit Extract, Corn syrup, Sodium hydroxide, Medium-chain triglycerides, Raphanus Sativus (Radish) Root Extract, Caramel, d-Limonene, Vegetable oil, Maltodextrin, Citric acid.

Risk Information
Consult a health care practitioner prior to use if you are taking blood thinners or blood pressure medication and/or if you are pregnant or breastfeeding.

To be sure this product is right for you always read and follow the label.

NPN 80083512