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Helps to promote healthy mood balance, relieve Fibromyalgia symptoms, and reduce the severity and duration of migraine headaches when taken as a prophylactic. 5·HTP Supreme™ is a synergistic formula of 5-hydroxytryptophan and vitamin B6 for supporting overall neurotransmitter metabolism by providing precursors of serotonin.

5-HTP SUPREME Medicinal Ingredients (per capsule):

L-5-Hydroxytryptophan (5-HTP, Grionia simplicifolia-Seed)............................100 mg

Vitamin B6(Pyridoxal 5-phosphate)................................................................................... 20 mg

Non-Medicinal Ingredients: Microcrystalline cellulose, hypromellose, L-leucine. Recommended Dose: Adults: Take 1 capsule three times per day, or as directed by your health care practitioner. To minimize the risk of gastrointestinal side eects, start dosing at 50-100 mg, 2-3 times per day and slowly increase to eective dose over 2 week period. Take with food. For symptoms of fibromyalgia, use for a minimum of 2 weeks to see beneficial eects. Consult a health care practitioner for use beyond one year.

WHY CONSIDER 5-HTP SUPPLEMENTATION?
Serotonin cannot cross the blood-brain barrier (BBB) and therefore must be manufactured within the central nervous system (CNS).2 Its precursor amino acid, L-tryptophan, easily crosses the BBB and, therefore, influences the rate of serotonin production. However, stress, elevated cortisol levels, vitamin B6 deficiency, and even high dosages of L-tryptophan (above 2,000 mg) can inhibit the production and transport of L-tryptophan from the bloodstream into the CNS. Further, the amount of L-tryptophan that passes into the brain is not only dependent on the amount found
in blood, but also its concentration relative to other amino acids. The conversion of L-tryptophan to 5-HTP is a rate-limited step in the production of serotonin.Therefore, it can be therapeutically advantageous to bypass this reaction and directly supply 5-HTP, which is easily absorbed in the gastrointestinal tract and crosses the BBB. Further, human clinical studies using 5-HTP have shown excellent safety with oral administration and 5-HTP supplementation has never been shown to cause the toxic serotonin syndrome. However, increasing the serotonin precursor, 5-HTP, could inadvertently decrease other neurotransmitters, including dopamine and norepinephrine, and exacerbate neuropsychiatric problems. Insomnia: Serotonin is a precursor to melatonin, the neurohormone that modulates circadian rhythms. Insuffcient serotonin can contribute to a lack of melatonin and cause insomnia; therefore, 5-HTP can help promote a balanced
sleep/wake cycle by maintaining adequate levels of serotonin.  Oral doses of 6 and 9mg/kg of 5-HTP was shown to increase sleep duration and decrease sleep latency time in animal studies. Appetite and Obesity: 5-HTP has been clinically studied as an influencer of food preferences which can be associated with obesity, disordered eating behaviour, and noncompliance with dietary restrictions. Conversely, macronutrient
ratios affect 5-HTP concentrations. Clinical studies in which obese women were given 5-HTP (8 mg kg−1 day−1) for 35 days showed weight loss, decreased food intake, and early satiety. Headaches and Migraines: Classic migraine headaches are more often experienced by women and thought to be anoutcome of low serotonin, high estrogen, and cortical excitability. In animal studies, 5-HTP administration in cycling
female rats decreased cortical spreading depression (CSD), the likely culprit of the migraine aura experienced in women during pregnancy and menstruation. Fibromyalgia and Chronic Pain Syndromes: The pain and symptoms experienced in many chronic pain syndromes such as fibromyalgia are often neuropathic and rooted in a hypervigilant central nervous system. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for the widespread symptoms associated with these conditions.  5-HTP is an alternative means of balancing serotonin and has been found to be deficient in those with fibromyalgia. In a systematic review, combination therapy of 5-HTP and a monoamine oxidate inhibitor (MAOI) significantly reduced pain scores in 200 human subjects with fibromyalgia, compared to monotherapy. 5-HTP co-administration
has also potentiated the eects of antihyperalgesic agents. Irritable Bowel Syndrome: Intestinal permeability, peristalsis, mucosal secretion, and visceral sensitivity are directly
associated with the serotonergic signaling pathways in the gastrointestinal tract. Individuals with IBS experience impaired intestinal barrier function as a result of alterations in serotonin metabolism. In clinical studies, oral administration of 5-HTP increased mucosal serotonergic metabolism, improving intestinal permeability in those with IBS. Designs for Health offers 5-HTP in two dosages: 50 mg per 1-capsule serving in 5-HTP Synergy™ and 100 mg per
1-capsule serving in 5-HTP Supreme™. Both products include vitamin B6, the necessary cofactor in the conversion of 5-HTP to serotonin.
5-HTP MAY HAVE BENEFICIAL PROPERTIES FOR:
• Mood disorders
• Excessive appetite
• Binge eating
• Carbohydrate cravings
• Obesity
• Headaches
• Migraines
• Insomnia
• Fibromyalgia
• Neuropathic pain
• Irritable Bowel Syndrome