Designs for Health’s Amino Acid Supreme™ is a concentrated, free-form, essential amino acid formula that features 2.5 g of the amino acid L-leucine per serving to promote muscle health and function, overall protein status, and homeostasis of the body.
Amino Acid Supreme™ is formulated with a pleasant-tasting, fruit punch flavour in a convenient powdered delivery for serving size flexibility. Alpha-ketoglutarate and the bioactive form of vitamin B6 (as pyridoxal-5-phosphate) are included to support
amino acid metabolism and bioavailability. Highlights
• Balanced mix of readily absorbable, free-form, essential amino acids in targeted amounts
• Features 2.5 g of L-leucine per serving to support sports nutrition and muscle health
• Zero grams of sugar
• Does not contain synthetic dyes or artificial sweeteners; sweetened with steviol glycosides from organic stevia leaf
• Convenient powdered delivery for serving size flexibility
• Pleasant-tasting fruit punch flavour
• Gluten-free, dairy-free, soy-free, and non-GMO

Amino acids are fundamental for a vast array of metabolic processes, as they are the basic building blocks for more than 100,000 unique proteins in the human body. They serve as the nitrogenous backbones for compounds (e.g., neurotransmitters,
hormones, and enzymes) and as intermediates in cellular metabolism. Amino acids also play a critical role in the metabolism and function of microorganisms in the  gastrointestinal tract. Insuffcient amino acid absorption may be a result of dietary and
lifestyle factors or digestive dysfunction, such as those that affect the proper functioning of the stomach, pancreas, liver, or small intestine. The precise amino acid content and sequence of a specific protein determines its biological activity. Proteins catalyze
most reactions in living cells and control virtually all cellular processes.

Ingredient Highlights
L-Leucine belongs to a special group of amino acids called branched-chain amino acids (BCAAs). BCAAs are required to help maintain and repair muscle tissue. Leucine is the most anabolic amino acid, and leucine-enriched amino acid intake has been
shown to stimulate protein synthesis in skeletal muscle by activating the mammalian target of rapamycin (mTOR) signaling pathway. Leucine is also necessary for the optimal growth of infants and for proper nitrogen balance in adults.

L-Isoleucine is another member of the BCAA family of amino acids. Isoleucine is needed for hemoglobin formation and helps to
maintain regular energy metabolism. It is also important for helping to support healthy blood sugar metabolism.

L-Valine is another BCAA that is closely related to leucine and isoleucine in its structure and function. Valine is a constituent of fibrous protein in the body and functions to promote muscle growth and regeneration. One of its metabolites, beta-aminoisobutyric acid, is secreted in skeletal muscle and acts on white adipose tissue to promote energy expenditure. In vitro and in vivo studies have shown that BCAA supplementation (either as a mixture or individually) may upregulate signaling pathways associated with mitochondrial biogenesis, such as peroxisome proliferator-activated receptor-gamma coactivator-1 alpha. However, more well-controlled human clinical trials are needed to fully elucidate the function of BCAAs on mitochondrial biogenesis and cellular energetics.
L-Arginine is considered a conditionally essential amino acid that plays an important role in cellular division, wound healing, and removing ammonia metabolites from the body. It is also important for healthy immune function, hormone release, and nitric
oxide production. In diet-induced obese rats, arginine supplementation was shown to promote lipolysis and reduce oxidative stress in white adipose tissue and in upregulated genes involved in mitochondrial biogenesis.

L-Histidine is the direct precursor to histamine and is essential for normal growth and tissue repair, and it helps to maintain the structure of the myelin sheaths that protect nerve cells. Histidine helps manufacture red and white blood cells and supports the
body’s ability to protect against the effects of heavy metals. Histamine is a biogenic amine and mediator of many biological processes, such as gastric secretions, vasodilation, inflammatory responses, bronchospasm, and neuromodulation.
L-Lysine is required for proper growth and bone development in children and is essential to produce carnitine. Lysine also helps the body absorb and conserve calcium, and it plays an important role in the formation of collagen.

L-Methionine is the first amino acid incorporated into the N-terminal position of all proteins, critically important for initiating messenger RNA translation. Methionine supplies sulfur and other compounds required by the body for normal metabolism,
detoxification, and growth. Methionine reacts with adenosine triphosphate (ATP) to form S-adenosylmethionine (SAM), the principal methyl donor in the body and key cofactor to the synthesis of many important compounds, including epinephrine
and choline.

L-Phenylalanine is needed for the biosynthesis of proteins, catecholamine neurotransmitters, and melanin. It is a precursor to the amino acid

L-tyrosine, which is then converted into the metabolites levodopa, dopamine, epinephrine, and norepinephrine.
L-Threonine plays an important role in the regulation of protein balance, energy metabolism, and nutrient absorption. It is critical in the formation of protein, collagen, elastin, and tooth enamel, and it is also an important component of gastrointestinal mucin, which serves as a barrier in the gut. L-threonine is involved in the production of T-lymphocytes, a component of the immune system, and facilitates lipotropic function and fat metabolism in the liver.
L-Tryptophan is a critical amino acid for nitrogen balance, the production of proteins, enzymes, muscles, and neurotransmitters, and for normal growth in infants. Tryptophan is the precursor to serotonin and melatonin, which help regulate circadian rhythm,
appetite, sleep, and mood. It also used by the liver for the biosynthesis of niacin (vitamin B3) and nicotinamide adenine dinucleotide, which is vital for energy metabolism and DNA production and repair.
Vitamin B6 (as pyridoxal-5-phosphate) is most well-known for its role in catalyzing many important steps in amino acid metabolism such as transamination, decarboxylation, and racemization. Alpha-ketoglutarate is the keto acid produced by deamination of glutamate and is a key intermediate in the citric acid cycle. It is one of the most important nitrogen transporters in metabolic pathways. Furthermore, it is transaminated to form glutamine, which can then be decarboxylated into the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), a reaction facilitated by vitamin B6.
BENEFITS:
• Supports protein status in the body • Helps maintain lean body mass
• May promote muscle protein synthesis • May help mitigate agerelated muscle loss
• May be beneficial for individuals with diffculty consuming adequate amounts of complete protein
Medicinal Ingredients (per 12 g / 1 scoop) :
L-Leucine........................................................................................................2.5 g
L-Phenylalanine.......................................................................................... 715 mg
L-Valine ..........................................................................................................615 mg
L-Histidine......................................................................................................590 mg
L-Arginine...................................................................................................... 525 mg
L-Isoleucine .................................................................................................. 525 mg
L-Lysine............................................................................................................ 525 mg
alpha-Ketoglutaric acid (2-Oxo-1,5-pentanedioic acid, 2-Oxoglutaric acid) ...........470 mg
L-Methionine................................................................................................435 mg
L-Threonine................................ ................................................................385 mg
L-Tryptophan ...............................................................................................120 mg
Vitamin B6 (Pyridoxal 5'-phosphate)................................................... 20 mg
Non-Medicinal Ingredients: Fruit punch flavour, natural flavour, partially hydrolysed guar gum, stevia leaf extract, citric acid,beet powder (colour).

Recommended Dose: Adults: Mix 12 g / 1 scoop well in 1-2 cups of water immediately before consumption
per day or as directed by your health care practitioner.